Alzheimer Disease as a Clinical-Biological Construct—An International Workin...

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[size=7.4835pt]FINDINGS [size=8.4813pt]In the new AA diagnostic criteria, AD can be defined clinically as encompassing
[size=8.4813pt]cognitively normal people having a core 1 AD biomarker. However, recent literature shows
[size=8.4813pt]that the majority of biomarker-positive cognitively normal individuals will not become
[size=8.4813pt]symptomatic along a proximate timeline. In the clinical setting, disclosing a diagnosis of AD
[size=8.4813pt]to cognitively normal people with only core 1 AD biomarkers re