肥大细胞与针灸镇痛
Abstract: Mast cells are widely distributed in various parts of the human body and play a vital role in the progression of many diseases. Recently, the close relationship between mast cells and acupoints was elucidated, and the role of mast cells in acupuncture analgesia has attracted the attention of researchers worldwide. Using mast cells, acupuncture analgesia and acupoint as key words to search CNKI, PubMed, Web of Science and other databases, combining the representative articles in these databases with the published research papers of our group, we summarized: The enrichment of mast cells and the dense arrangement of collagen fibers, microvessels, and nerves form the basis for acupoints as the reaction sites of acupuncture; acupuncture can cause the deformation of collagen fibers and activate TRPV channels on mast cells membrane, so as to stimulate mast cells to release bioactive substances and activate nerve receptors to generate analgesic effect; system biology models are set up to explain the quantitative process of information initiation and transmission at acupuncture points, and indicate that the acupuncture effect depends on the local mast cells density.In a conclusion, this review will give a scientific explanation of acupuncture analgesia from the material basis of acupoints, the local initiation, and afferent biological mechanism.
摘要：肥大细胞广泛分布于人体各部位，在许多疾病的进展中起着至关重要的作用。近年来，肥大细胞与穴位之间的密切关系被阐明，肥大细胞在针灸镇痛中的作用引起了世界各地研究人员的关注。以肥大细胞、针灸镇痛和穴位为关键词检索CNKI、PubMed、Web of Science等数据库，结合这些数据库中的代表性文章和本组已发表的研究论文，我们总结出：肥大细胞的富集和胶原纤维、微血管的密集排列，神经是穴位作为针刺反应部位的基础；针刺可引起胶原纤维变形，激活肥大细胞膜上的TRPV通道，从而刺激肥大细胞释放生物活性物质，激活神经受体产生镇痛作用；系统生物学模型设置为u
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